[HTML][HTML] Receptor interacting protein 3 suppresses vascular smooth muscle cell growth by inhibition of the phosphoinositide 3-kinase-Akt axis

Q Li, G Li, X Lan, M Zheng, KH Chen, CM Cao… - Journal of biological …, 2010 - ASBMB
Proliferation of vascular smooth muscle cells (VSMCs) is a primary mechanism underlying
cardiovascular proliferative disorders. Phosphoinositide 3-kinase (PI3K)-Akt (or protein
kinase B) axis has been assigned at the center of pathways that regulate cell proliferation.
Here we demonstrate that enhanced PI3K-Akt signaling by mitogenic stimulation or arterial
injury profoundly elevates expression of receptor interacting protein 3 (RIP3) in primary
cultured rat VSMCs and in vivo and that the up-regulation of RIP3 leads to VSMC growth …