A recombinant antibody with the antigen-specific, major histocompatibility complex-restricted specificity of T cells.

PS Andersen, A Stryhn, BE Hansen… - Proceedings of the …, 1996 - National Acad Sciences
PS Andersen, A Stryhn, BE Hansen, L Fugger, J Engberg, S Buus
Proceedings of the National Academy of Sciences, 1996National Acad Sciences
Specific recognition of peptide/major histocompatibility complex (MHC) molecule complexes
by the T-cell receptor is a key reaction in the specific immune response. Antibodies against
peptide/MHC complexes would therefore be valuable tools in studying MHC function and T-
cell recognition and might lead to novel approaches in immunotherapy. However, it has
proven difficult to generate antibodies with the specificity of T cells by conventional
hybridoma techniques. Here we report that the phage display technology is a feasible …
Specific recognition of peptide/major histocompatibility complex (MHC) molecule complexes by the T-cell receptor is a key reaction in the specific immune response. Antibodies against peptide/MHC complexes would therefore be valuable tools in studying MHC function and T-cell recognition and might lead to novel approaches in immunotherapy. However, it has proven difficult to generate antibodies with the specificity of T cells by conventional hybridoma techniques. Here we report that the phage display technology is a feasible alternative to generate antibodies recognizing specific, predetermined peptide/MHC complexes.
National Acad Sciences