How TCRs bind MHCs, peptides, and coreceptors
MG Rudolph, RL Stanfield, IA Wilson - Annu. Rev. Immunol., 2006 - annualreviews.org
Since the first crystal structure determinations of αβ T cell receptors (TCRs) bound to class I
MHC-peptide (pMHC) antigens in 1996, a sizable database of 24 class I and class II
TCR/pMHC complexes has been accumulated that now defines a substantial degree of
structural variability in TCR/pMHC recognition. Recent determination of free and bound γδ
TCR structures has enabled comparisons of the modes of antigen recognition by αβ and γδ
T cells and antibodies. Crystal structures of TCR accessory (CD4, CD8) and coreceptor …
MHC-peptide (pMHC) antigens in 1996, a sizable database of 24 class I and class II
TCR/pMHC complexes has been accumulated that now defines a substantial degree of
structural variability in TCR/pMHC recognition. Recent determination of free and bound γδ
TCR structures has enabled comparisons of the modes of antigen recognition by αβ and γδ
T cells and antibodies. Crystal structures of TCR accessory (CD4, CD8) and coreceptor …