Effect of vericiguat, a soluble guanylate cyclase stimulator, on natriuretic peptide levels in patients with worsening chronic heart failure and reduced ejection fraction …
Importance Worsening chronic heart failure (HF) is a major public health problem. Objective
To determine the optimal dose and tolerability of vericiguat, a soluble guanylate cyclase
stimulator, in patients with worsening chronic HF and reduced left ventricular ejection
fraction (LVEF). Design, Setting, and Participants Dose-finding phase 2 study that
randomized 456 patients across Europe, North America, and Asia between November 2013
and January 2015, with follow-up ending June 2015. Patients were clinically stable with …
To determine the optimal dose and tolerability of vericiguat, a soluble guanylate cyclase
stimulator, in patients with worsening chronic HF and reduced left ventricular ejection
fraction (LVEF). Design, Setting, and Participants Dose-finding phase 2 study that
randomized 456 patients across Europe, North America, and Asia between November 2013
and January 2015, with follow-up ending June 2015. Patients were clinically stable with …
