The kidney in heart failure

PJ Cannon - New England Journal of Medicine, 1977 - Mass Medical Soc
PJ Cannon
New England Journal of Medicine, 1977Mass Medical Soc
The kidneys participate to a major extent in the pathogenesis of congestive heart failure.
When the heart fails as a pump, a complex alteration of homeostatic mechanisms results.
Among the adjustments that occur are changes in the hemodynamic and hormonal
mechanisms that regulate the volume and tonicity of the extracellular fluid so that the ability
of the kidneys to excrete salt and water is reduced. 1 Retention of sodium chloride and water
expands the volume of the extracellular fluid, which, in turn, may produce circulatory …
The kidneys participate to a major extent in the pathogenesis of congestive heart failure. When the heart fails as a pump, a complex alteration of homeostatic mechanisms results. Among the adjustments that occur are changes in the hemodynamic and hormonal mechanisms that regulate the volume and tonicity of the extracellular fluid so that the ability of the kidneys to excrete salt and water is reduced.1 Retention of sodium chloride and water expands the volume of the extracellular fluid, which, in turn, may produce circulatory congestion and edema. This article is a review of some of the physiologic alterations that participate . . .
The New England Journal Of Medicine