Further characterization of the metabolic properties of triglyceride-rich lipoproteins from human and mouse apoC-III transgenic mice.
K Aalto-Setälä, PH Weinstock, CL Bisgaier, L Wu… - Journal of lipid …, 1996 - jlr.org
We previously showed that human apoC-III expression in transgenic mice causes
hypertriglyceridemia due to the accumulation of enlarged very low density lipoprotein
(VLDL)-like particles, with increased triglycerides and apoC-III and decreased apoE. In vivo
turnover studies indicated the metabolic basis was decreased particle fractional catabolic
rate. The presence of enlarged triglyceride-rich particles with prolonged residence time in
plasma implied defective lipolysis, but in vitro these particles were good substrates for …
hypertriglyceridemia due to the accumulation of enlarged very low density lipoprotein
(VLDL)-like particles, with increased triglycerides and apoC-III and decreased apoE. In vivo
turnover studies indicated the metabolic basis was decreased particle fractional catabolic
rate. The presence of enlarged triglyceride-rich particles with prolonged residence time in
plasma implied defective lipolysis, but in vitro these particles were good substrates for …
