[HTML][HTML] Two-step mechanism of binding of apolipoprotein E to heparin: implications for the kinetics of apolipoprotein E-heparan sulfate proteoglycan complex …
M Futamura, P Dhanasekaran, T Handa… - Journal of Biological …, 2005 - ASBMB
The interaction of apolipoprotein E (apoE) with cell-surface heparan sulfate proteoglycans is
an important step in the uptake of lipoprotein remnants by the liver. ApoE interacts
predominantly with heparin through the N-terminal binding site spanning the residues
around 136–150. In this work, surface plasmon resonance analysis was employed to
investigate how amphipathic α-helix properties and basic residue organization in this region
modulate binding of apoE to heparin. The apoE/heparin interaction involves a two-step …
an important step in the uptake of lipoprotein remnants by the liver. ApoE interacts
predominantly with heparin through the N-terminal binding site spanning the residues
around 136–150. In this work, surface plasmon resonance analysis was employed to
investigate how amphipathic α-helix properties and basic residue organization in this region
modulate binding of apoE to heparin. The apoE/heparin interaction involves a two-step …