Upregulation by retinoic acid of interleukin-2-receptor mRNA in human T lymphocytes
N Sidell, B Chang, L Bhatti - Cellular immunology, 1993 - Elsevier
It was previously demonstrated that retinoic acid (RA) can enhance the functional responses
of human T lymphocytes by increasing surface IL-2Rα chain protein expression on
proliferating T blasts, resulting in augmented IL-2-dependent growth. In the present study,
we used IL-2-maintained lymphoblasts generated from human thymocytes to show that RA
enhancement of IL-2Rα is accompanied by an increase in steady-state levels of IL-2Rα
mRNA. This increase occurred within 1 hr after the addition of RA to the culture and was …
of human T lymphocytes by increasing surface IL-2Rα chain protein expression on
proliferating T blasts, resulting in augmented IL-2-dependent growth. In the present study,
we used IL-2-maintained lymphoblasts generated from human thymocytes to show that RA
enhancement of IL-2Rα is accompanied by an increase in steady-state levels of IL-2Rα
mRNA. This increase occurred within 1 hr after the addition of RA to the culture and was …