Human airway ion transport. Part two.
RC Boucher - American journal of respiratory and critical care …, 1994 - atsjournals.org
American journal of respiratory and critical care medicine, 1994•atsjournals.org
Cellular ion-transport processes depend on the availability of ATP generated through
metabolic processes. The effects of inhibition of active cellular metabolism have only been
studied in model airway epithelia (142). However, it is likely that processes that perturb
oxidative metabolism will likewise inhibit Na+ absorption and transcellular CI-flow, perhaps
via interactions with CFTR (143, 144), in human airway epithelia. Na+ Transport Regulation
Theoretically, Na'-transport processes are subject to acute (Le., seconds to minutes) and …
metabolic processes. The effects of inhibition of active cellular metabolism have only been
studied in model airway epithelia (142). However, it is likely that processes that perturb
oxidative metabolism will likewise inhibit Na+ absorption and transcellular CI-flow, perhaps
via interactions with CFTR (143, 144), in human airway epithelia. Na+ Transport Regulation
Theoretically, Na'-transport processes are subject to acute (Le., seconds to minutes) and …
Cellular ion-transport processes depend on the availability of ATP generated through metabolic processes. The effects of inhibition of active cellular metabolism have only been studied in model airway epithelia (142). However, it is likely that processes that perturb oxidative metabolism will likewise inhibit Na+ absorption and transcellular CI-flow, perhaps via interactions with CFTR (143, 144), in human airway epithelia.
Na+ Transport Regulation Theoretically, Na'-transport processes are subject to acute (Le., seconds to minutes) and chronic (Le., hours to days) regulation. Little is known about the acute or chronic regulation of Na+ transport in human airways. This is surprising, given the fact that Na+ absorption represents the major active ion-transport activity of the human airway epithelia, and regulation presumably is required to finely adjust the volume of ASL on airway surfaces.
ATS Journals