ΔF508 CFTR processing correction and activity in polarized airway and non-airway cell monolayers
SM Rowe, LC Pyle, A Jurkevante, K Varga… - Pulmonary …, 2010 - Elsevier
We examined the activity of ΔF508 cystic fibrosis transmembrane conductance regulator
(CFTR) stably expressed in polarized cystic fibrosis bronchial epithelial cells (CFBE41o−)
human airway cells and Fisher Rat Thyroid (FRT) cells following treatment with low
temperature and a panel of small molecule correctors of ΔF508 CFTR misprocessing. Corr-
4a increased ΔF508 CFTR-dependent Cl− conductance in both cell types, whereas
treatment with VRT-325 or VRT-640 increased activity only in FRT cells. Total currents …
(CFTR) stably expressed in polarized cystic fibrosis bronchial epithelial cells (CFBE41o−)
human airway cells and Fisher Rat Thyroid (FRT) cells following treatment with low
temperature and a panel of small molecule correctors of ΔF508 CFTR misprocessing. Corr-
4a increased ΔF508 CFTR-dependent Cl− conductance in both cell types, whereas
treatment with VRT-325 or VRT-640 increased activity only in FRT cells. Total currents …