Stimulation of औ2-Adrenergic Receptor Increases Cystic Fibrosis Transmembrane Conductance Regulator Expression in Human Airway Epithelial Cells through a …
K Taouil, J Hinnrasky, C Hologne, P Corlieu… - Journal of Biological …, 2003 - jbc.org
PSD-95/Dlg-A/ZO-1 (PDZ) domains play an essential role in determining cell polarity. The
Na+/H+ exchanger regulatory factor (NHERF), also known as EBP50, contains two PDZ
domains that mediate the assembly of transmembrane and cytosolic proteins into functional
signal transduction complexes. Moreover, it has been shown that cystic fibrosis
transmembrane conductance regulator (CFTR) and औ 2-adrenergic receptor (औ 2 AR) bind
equally well to the PDZ1 domain of EBP50. We hypothesized that औ 2 AR activation may …
Na+/H+ exchanger regulatory factor (NHERF), also known as EBP50, contains two PDZ
domains that mediate the assembly of transmembrane and cytosolic proteins into functional
signal transduction complexes. Moreover, it has been shown that cystic fibrosis
transmembrane conductance regulator (CFTR) and औ 2-adrenergic receptor (औ 2 AR) bind
equally well to the PDZ1 domain of EBP50. We hypothesized that औ 2 AR activation may …
