Regulation of adenylyl cyclase by protein kinase A
G Iwami, J Kawabe, T Ebina, PJ Cannon… - Journal of Biological …, 1995 - jbc.org
The changing relationship between stimuli and responses after prolonged receptor
stimulation is a general feature of hormonal signaling systems, termed desensitization. This
phenomenon has been best exemplified in the covalent modification of the G protein-linked
catecholamine receptors. However, other components within this signaling pathway can be
involved in desensitization. Here we present evidence that desensitization occurs at the
level of the effector enzyme itself through phosphorylation. Type V adenylyl cyclase (AC) is …
stimulation is a general feature of hormonal signaling systems, termed desensitization. This
phenomenon has been best exemplified in the covalent modification of the G protein-linked
catecholamine receptors. However, other components within this signaling pathway can be
involved in desensitization. Here we present evidence that desensitization occurs at the
level of the effector enzyme itself through phosphorylation. Type V adenylyl cyclase (AC) is …
