Comparative effects of salmeterol, albuterol, and ipratropium on normal and impaired mucociliary function in sheep
JR Sabater, TA Lee, WM Abraham - Chest, 2005 - Elsevier
Study objective: We measured tracheal mucus velocity (TMV), a marker of mucociliary
clearance (MCC), in sheep before and for 12 h after treatment with salmeterol, albuterol,
ipratropium, or vehicle to determine the effects on normal MCC. We also determined if these
agents could reverse the depression in TMV caused by inhaled human neutrophil elastase
(HNE), a model of abnormal MCC. Methods: Study 1: TMV was measured initially and then
for 6 h after metered-dose inhaler treatment with salmeterol (42 μg), albuterol (180 μg) …
clearance (MCC), in sheep before and for 12 h after treatment with salmeterol, albuterol,
ipratropium, or vehicle to determine the effects on normal MCC. We also determined if these
agents could reverse the depression in TMV caused by inhaled human neutrophil elastase
(HNE), a model of abnormal MCC. Methods: Study 1: TMV was measured initially and then
for 6 h after metered-dose inhaler treatment with salmeterol (42 μg), albuterol (180 μg) …