G proteins
JR Hepler, AG Gilman - Trends in biochemical sciences, 1992 - Elsevier
JR Hepler, AG Gilman
Trends in biochemical sciences, 1992•ElsevierThe family of heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins)
serves an essential role in transducing receptor-generated signals across the plasma
membrane. Recent findings reveal unexpected functional roles for individual G protein
subunits. Thus, GTP-binding α-subunits and the βγ-subunit complex can influence the
activity of effector molecules independently or simultaneously, either synergistically or in
opposition, to elicit a complex constellation of cellular events.
serves an essential role in transducing receptor-generated signals across the plasma
membrane. Recent findings reveal unexpected functional roles for individual G protein
subunits. Thus, GTP-binding α-subunits and the βγ-subunit complex can influence the
activity of effector molecules independently or simultaneously, either synergistically or in
opposition, to elicit a complex constellation of cellular events.
Abstract
The family of heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) serves an essential role in transducing receptor-generated signals across the plasma membrane. Recent findings reveal unexpected functional roles for individual G protein subunits. Thus, GTP-binding α-subunits and the βγ-subunit complex can influence the activity of effector molecules independently or simultaneously, either synergistically or in opposition, to elicit a complex constellation of cellular events.
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