[HTML][HTML] Dynamic regulation of cystic fibrosis transmembrane conductance regulator by competitive interactions of molecular adaptors
Disorganized ion transport caused by hypo-or hyperfunctioning of the cystic fibrosis
transmembrane conductance regulator (CFTR) can be detrimental and may result in life-
threatening diseases such as cystic fibrosis or secretory diarrhea. Thus, CFTR is controlled
by elaborate positive and negative regulations for an efficient homeostasis. It has been
shown that expression and activity of CFTR can be regulated either positively or negatively
by PDZ (PSD-95/discs large/ZO-1) domain-based adaptors. Although a positive regulation …
transmembrane conductance regulator (CFTR) can be detrimental and may result in life-
threatening diseases such as cystic fibrosis or secretory diarrhea. Thus, CFTR is controlled
by elaborate positive and negative regulations for an efficient homeostasis. It has been
shown that expression and activity of CFTR can be regulated either positively or negatively
by PDZ (PSD-95/discs large/ZO-1) domain-based adaptors. Although a positive regulation …