A conserved region of the R domain of cystic fibrosis transmembrane conductance regulator is important in processing and function
EA Pasyk, XK Morin, P Zeman, E Garami… - Journal of Biological …, 1998 - ASBMB
The R domain of cystic fibrosis transmembrane conductance regulator (CFTR) connects the
two halves of the protein, each of which possess a transmembrane-spanning domain and a
nucleotide binding domain. Phosphorylation of serine residues, which reside mostly within
the C-terminal two-thirds of the R domain, is required for nucleotide-dependent activation of
CFTR chloride channel activity. The N terminus of the R domain is also likely to be important
in CFTR function, since this region is highly conserved among CFTRs of different species …
two halves of the protein, each of which possess a transmembrane-spanning domain and a
nucleotide binding domain. Phosphorylation of serine residues, which reside mostly within
the C-terminal two-thirds of the R domain, is required for nucleotide-dependent activation of
CFTR chloride channel activity. The N terminus of the R domain is also likely to be important
in CFTR function, since this region is highly conserved among CFTRs of different species …
