Natural progression of atherosclerosis from pathologic intimal thickening to late fibroatheroma in human coronary arteries: a pathology study
F Otsuka, MCA Kramer, P Woudstra, K Yahagi… - Atherosclerosis, 2015 - Elsevier
Objective Smooth muscle cells, macrophage infiltration and accumulation of lipids,
proteoglycans, collagen matrix and calcification play a central role in atherosclerosis. The
early histologic changes of plaque progression from pathologic intimal thickenings (PIT) to
late fibroatheroma lesions have not been fully characterized. Methods A total of 151
atherosclerotic coronary lesions were collected from 67 sudden death victims.
Atherosclerotic plaques were classified as PIT without macrophage infiltration, PIT with …
proteoglycans, collagen matrix and calcification play a central role in atherosclerosis. The
early histologic changes of plaque progression from pathologic intimal thickenings (PIT) to
late fibroatheroma lesions have not been fully characterized. Methods A total of 151
atherosclerotic coronary lesions were collected from 67 sudden death victims.
Atherosclerotic plaques were classified as PIT without macrophage infiltration, PIT with …