Atherosclerosis, a chronic inflammatory disorder of the arteries, is responsible for most
deaths in westernized societies with numbers increasing at a marked rate in developing
countries. The disease is initiated by the activation of the endothelium by various risk factors
leading to chemokine-mediated recruitment of immune cells. The uptake of modified
lipoproteins by macrophages along with defective cholesterol efflux gives rise to foam cells
associated with the fatty streak in the early phase of the disease. As the disease progresses …