[CITATION][C] Circulatory support with attenuated pulse pressure alters human aortic wall morphology
S Westaby, GB Bertoni, C Clelland, T Nishinaka… - The Journal of thoracic …, 2007 - jtcvs.org
One study limitation is that the autopsy samples could not be compared with the same
patients' aorta obtained during LVAD implantation. However, we were initially unaware of
the sheep findings from our Terumo ventricular assist device program. 2 It was this that
triggered the human study. Matched controls were the alternative. Irrespective of this, the
human changes closely parallel the laboratory findings. 3 Arteries remodel in response to
pressure and flow to provide a constant level of shear stress. Remodeling follows a complex …
patients' aorta obtained during LVAD implantation. However, we were initially unaware of
the sheep findings from our Terumo ventricular assist device program. 2 It was this that
triggered the human study. Matched controls were the alternative. Irrespective of this, the
human changes closely parallel the laboratory findings. 3 Arteries remodel in response to
pressure and flow to provide a constant level of shear stress. Remodeling follows a complex …