New therapy, new challenges: the effects of long-term continuous flow left ventricular assist device on inflammation

L Grosman-Rimon, F Billia, A Fuks, I Jacobs… - International Journal of …, 2016 - Elsevier
L Grosman-Rimon, F Billia, A Fuks, I Jacobs, MA McDonald, DZ Cherney, V Rao
International Journal of Cardiology, 2016Elsevier
Surgically implanted continuous flow left ventricular assist devices (CF-LVADs) are currently
used in patients with end-stage heart failure (HF). However, CF-LVAD therapy introduces a
new set of complications and adverse events in these patients. Major adverse events with
the CF-LVAD include right heart failure, vascular dysfunction, stroke, hepatic failure, and
multi-organ failure, complications that may have inflammation as a common etiology. Our
aim was to review the current evidence showing a relationship between these adverse …
Abstract
Surgically implanted continuous flow left ventricular assist devices (CF-LVADs) are currently used in patients with end-stage heart failure (HF). However, CF-LVAD therapy introduces a new set of complications and adverse events in these patients. Major adverse events with the CF-LVAD include right heart failure, vascular dysfunction, stroke, hepatic failure, and multi-organ failure, complications that may have inflammation as a common etiology. Our aim was to review the current evidence showing a relationship between these adverse events and elevated levels of inflammatory biomarkers in CF-LVAD recipients.
Elsevier