Cell biology and pathology of podocytes
A Greka, P Mundel - Annual review of physiology, 2012 - annualreviews.org
As an integral member of the filtration barrier in the kidney glomerulus, the podocyte is in a
unique geographical position: It is exposed to chemical signals from the urinary space
(Bowman's capsule), it receives and transmits chemical and mechanical signals to/from the
glomerular basement membrane upon which it elaborates, and it receives chemical and
mechanical signals from the vascular space with which it also communicates. As with every
cell, the ability of the podocyte to receive signals from the surrounding environment and to …
unique geographical position: It is exposed to chemical signals from the urinary space
(Bowman's capsule), it receives and transmits chemical and mechanical signals to/from the
glomerular basement membrane upon which it elaborates, and it receives chemical and
mechanical signals from the vascular space with which it also communicates. As with every
cell, the ability of the podocyte to receive signals from the surrounding environment and to …