[HTML][HTML] Role of TNFα in early chemokine production and leukocyte infiltration into heart allografts
D Ishii, AD Schenk, S Baba, RL Fairchild - American Journal of …, 2010 - Elsevier
The acute phase cytokines IL‐1β, IL‐6 and TNFα are produced early during inflammatory
processes, including ischemia‐reperfusion. The appearance and role of these cytokines in
the early inflammation following reperfusion of grafts remain poorly defined. This study
investigated the role of TNFα in the induction of early leukocyte infiltration into vascularized
heart allografts. TNFα and IL‐6 mRNA levels reached an initial peak 3 h posttransplant and
a second peak at 9–12 h with equivalent levels in iso‐and allografts. A single dose of anti …
processes, including ischemia‐reperfusion. The appearance and role of these cytokines in
the early inflammation following reperfusion of grafts remain poorly defined. This study
investigated the role of TNFα in the induction of early leukocyte infiltration into vascularized
heart allografts. TNFα and IL‐6 mRNA levels reached an initial peak 3 h posttransplant and
a second peak at 9–12 h with equivalent levels in iso‐and allografts. A single dose of anti …