[HTML][HTML] Evidence for cooperativity in the rejection of cardiac grafts mediated by CD4+ TCR Tg T cells specific for a defined allopeptide
K Honjo, XY Xu, JA Kapp, RP Bucy - American Journal of Transplantation, 2004 - Elsevier
Understanding the mechanisms of rejection of organs transplanted between unrelated
individuals is confounded by the complexity of the alloantigens and the diversity of T cells
responding to these alloantigens. To circumvent these problems, we developed a transgenic
(Tg) C57BL/6 model system in which the T-cell receptor (TCR) expressed by CD4 T cells is
specific for a defined allogeneic H-2K d peptide and the cardiac donor expressed H-2K d as
a transgene on the C57BL/6 background (B6. K d). These TCR Tg T cells were previously …
individuals is confounded by the complexity of the alloantigens and the diversity of T cells
responding to these alloantigens. To circumvent these problems, we developed a transgenic
(Tg) C57BL/6 model system in which the T-cell receptor (TCR) expressed by CD4 T cells is
specific for a defined allogeneic H-2K d peptide and the cardiac donor expressed H-2K d as
a transgene on the C57BL/6 background (B6. K d). These TCR Tg T cells were previously …