Regulation of human cytolytic lymphocyte responses by interleukin-12
MK Gately, AG Wolitzky, PM Quinn, R Chizzonite - Cellular immunology, 1992 - Elsevier
IL-12 is a heterodimeric cytokine which has been shown to cause the proliferation of
activated T and NK cells, to enhance the lytic activity of NK cells, and to induce IFN-γ
production by resting and activated T and NK cells. We previously reported that IL-12 could
synergize with IL-2 to activate human LAK cells in the presence of hydrocortisone but that IL-
12 alone was inactive. We herein show that in the absence of hydrocortisone, IL-12 by itself
can activate human LAK cells. IL-12-induced LAK cell activity was mediated predominantly …
activated T and NK cells, to enhance the lytic activity of NK cells, and to induce IFN-γ
production by resting and activated T and NK cells. We previously reported that IL-12 could
synergize with IL-2 to activate human LAK cells in the presence of hydrocortisone but that IL-
12 alone was inactive. We herein show that in the absence of hydrocortisone, IL-12 by itself
can activate human LAK cells. IL-12-induced LAK cell activity was mediated predominantly …
