[HTML][HTML] Selective targeting of high-affinity LFA-1 does not augment costimulation blockade in a nonhuman primate renal transplantation model
KP Samy, DJ Anderson, DJ Lo, MS Mulvihill… - American Journal of …, 2017 - Elsevier
Costimulation blockade (CoB) via belatacept is a lower-morbidity alternative to calcineurin
inhibitor (CNI)-based immunosuppression. However, it has higher rates of early acute
rejection. These early rejections are mediated in part by memory T cells, which have
reduced dependence on the pathway targeted by belatacept and increased adhesion
molecule expression. One such molecule is leukocyte function antigen (LFA)-1. LFA-1 exists
in two forms: a commonly expressed, low-affinity form and a transient, high-affinity form …
inhibitor (CNI)-based immunosuppression. However, it has higher rates of early acute
rejection. These early rejections are mediated in part by memory T cells, which have
reduced dependence on the pathway targeted by belatacept and increased adhesion
molecule expression. One such molecule is leukocyte function antigen (LFA)-1. LFA-1 exists
in two forms: a commonly expressed, low-affinity form and a transient, high-affinity form …
