[HTML][HTML] Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis

C Cole, K Kroboth, NJ Schurch, A Sandilands… - Journal of Allergy and …, 2014 - Elsevier
Background Atopic dermatitis (AD; eczema) is characterized by a widespread abnormality in
cutaneous barrier function and propensity to inflammation. Filaggrin is a multifunctional
protein and plays a key role in skin barrier formation. Loss-of-function mutations in the gene
encoding filaggrin (FLG) are a highly significant risk factor for atopic disease, but the
molecular mechanisms leading to dermatitis remain unclear. Objective We sought to
interrogate tissue-specific variations in the expressed genome in the skin of children with AD …