Lipidomic analysis of epidermal lipids: a tool to predict progression of inflammatory skin disease in humans
S Li, G Ganguli-Indra, AK Indra - Expert review of proteomics, 2016 - Taylor & Francis
S Li, G Ganguli-Indra, AK Indra
Expert review of proteomics, 2016•Taylor & FrancisIntroduction: Lipidomics is the large-scale profiling and characterization of lipid species in a
biological system using mass spectrometry. The skin barrier is mainly comprised of
corneocytes and a lipid-enriched extracellular matrix. The major skin lipids are ceramides,
cholesterol and free fatty acids (FFA). Lipid compositions are altered in inflammatory skin
disorders with disrupted skin barrier such as atopic dermatitis (AD). Areas covered: Here we
discuss some of the recent applications of lipidomics in human skin biology and in …
biological system using mass spectrometry. The skin barrier is mainly comprised of
corneocytes and a lipid-enriched extracellular matrix. The major skin lipids are ceramides,
cholesterol and free fatty acids (FFA). Lipid compositions are altered in inflammatory skin
disorders with disrupted skin barrier such as atopic dermatitis (AD). Areas covered: Here we
discuss some of the recent applications of lipidomics in human skin biology and in …
Abstract
Introduction: Lipidomics is the large-scale profiling and characterization of lipid species in a biological system using mass spectrometry. The skin barrier is mainly comprised of corneocytes and a lipid-enriched extracellular matrix. The major skin lipids are ceramides, cholesterol and free fatty acids (FFA). Lipid compositions are altered in inflammatory skin disorders with disrupted skin barrier such as atopic dermatitis (AD).
Areas covered: Here we discuss some of the recent applications of lipidomics in human skin biology and in inflammatory skin diseases such as AD, psoriasis and Netherton syndrome. We also review applications of lipidomics in human skin equivalent and in pre-clinical animal models of skin diseases to gain insight into the pathogenesis of the skin disease.
Expert commentary: Skin lipidomics analysis could be a fast, reliable and noninvasive tool to characterize the skin lipid profile and to monitor the progression of inflammatory skin diseases such as AD.
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