[HTML][HTML] WNT1-induced secreted protein-1 (WISP1), a novel regulator of bone turnover and Wnt signaling

A Maeda, M Ono, K Holmbeck, L Li, TM Kilts… - Journal of Biological …, 2015 - ASBMB
WISP1/CCN4 (hereafter referred to as WISP1), a member of the CCN family, is found in
mineralized tissues and is produced by osteoblasts and their precursors. In this study, Wisp1-
deficient (Wisp1−/−) mice were generated. Using dual-energy x-ray absorptiometry, we
showed that by 3 months, the total bone mineral density of Wisp1−/− mice was significantly
lower than that of WT mice. Further investigation by micro-computed tomography showed
that female Wisp1−/− mice had decreased trabecular bone volume/total volume and that …