Mouse models are a valuable tool for studying acute injury and chronic remodeling of the
myocardium in vivo. With the advent of genetic modifications to the whole organism or the
myocardium and an array of biological and/or synthetic materials, there is great potential for
any combination of these to assuage the extent of acute ischemic injury and impede the
onset of heart failure pursuant to myocardial remodeling. Here we present the methods and
materials used to reliably perform this microsurgery and the modifications involved for …