[HTML][HTML] The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen
L del Peso, MC Castellanos, E Temes… - Journal of Biological …, 2003 - ASBMB
Most of the genes induced by hypoxia are regulated by a family of transcription factors
termed hypoxia-inducible factors (HIF). Under normoxic conditions, HIFα proteins are very
unstable due to hydroxylation by a recently described family of proline hydroxylases termed
EGL-Nine homologs (EGLN). Upon hydroxylation, HIFα is recognized by the product of the
tumor suppressor vhl and targeted for proteosomal degradation. Since EGLNs require
oxygen to catalize HIF hydroxylation, this reaction does not efficiently occur under low …
termed hypoxia-inducible factors (HIF). Under normoxic conditions, HIFα proteins are very
unstable due to hydroxylation by a recently described family of proline hydroxylases termed
EGL-Nine homologs (EGLN). Upon hydroxylation, HIFα is recognized by the product of the
tumor suppressor vhl and targeted for proteosomal degradation. Since EGLNs require
oxygen to catalize HIF hydroxylation, this reaction does not efficiently occur under low …