Renal cell carcinoma (RCC) includes a variety of disparate diseases, each of which displays
interesting and novel molecular features, challenging some of the central tenets of cancer
biology and lending unique insights into cancer-promoting mechanisms. The prevailing
literature has focused on the most common type, the clear cell renal cell carcinoma (ccRCC)
subgroup, in which familial and sporadic disease demonstrate similar molecular profiles.
ccRCC is dominated by inactivating mutations in VHL, leading to constitutive activation of …