The instructive role of dendritic cells on T cell responses: lineages, plasticity and kinetics

A Lanzavecchia, F Sallusto - Current opinion in immunology, 2001 - Elsevier
Current opinion in immunology, 2001Elsevier
Dendritic cells are responsible for directing different types of T cell responses, from thymic
negative selection to the generation of effector and memory cells and the induction of
peripheral tolerance. Recent studies indicate that the dendritic cell lineage, the extent of
recruitment into inflamed tissues and migration to lymph nodes, the nature of maturation
stimuli and the kinetics of activation have a quantitative and qualitative impact on T cell
stimulation, thus exerting an instructive control on T cell responses.
Dendritic cells are responsible for directing different types of T cell responses, from thymic negative selection to the generation of effector and memory cells and the induction of peripheral tolerance. Recent studies indicate that the dendritic cell lineage, the extent of recruitment into inflamed tissues and migration to lymph nodes, the nature of maturation stimuli and the kinetics of activation have a quantitative and qualitative impact on T cell stimulation, thus exerting an instructive control on T cell responses.
Elsevier