[PDF][PDF] Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma
K Trunzer, AC Pavlick, L Schuchter… - Journal of clinical …, 2013 - researchgate.net
Journal of clinical oncology, 2013•researchgate.net
Purpose To assess pharmacodynamic effects and intrinsic and acquired resistance
mechanisms of the BRAF inhibitor vemurafenib in BRAFV600-mutant melanoma, leading to
an understanding of the mechanism of action of vemurafenib and ultimately to optimization
of metastatic melanoma therapy.
mechanisms of the BRAF inhibitor vemurafenib in BRAFV600-mutant melanoma, leading to
an understanding of the mechanism of action of vemurafenib and ultimately to optimization
of metastatic melanoma therapy.
Purpose
To assess pharmacodynamic effects and intrinsic and acquired resistance mechanisms of the BRAF inhibitor vemurafenib in BRAFV600-mutant melanoma, leading to an understanding of the mechanism of action of vemurafenib and ultimately to optimization of metastatic melanoma therapy.
researchgate.net