High nuclear expression of phosphorylated extracellular signal–regulated kinase in tumor cells in colorectal glands is associated with poor outcome in colorectal …
CJ Tai, CH Lee, HC Chen, HK Wang, MC Jiang… - Annals of Diagnostic …, 2013 - Elsevier
Extracellular signal–regulated kinase (ERK) is a major downstream transducer of Ras and
plays an important role in transducing extracellular signals to the nuclei of cells. It is located
in both the cytoplasm and the nucleus of cells. The nuclear localization of phosphorylated or
activated ERK is involved in the invasive behavior of tumor cells. We studied the association
between Ras mutation/ERK activation and the prognosis of patients with colorectal cancer.
We analyzed 126 surgically resected colorectal cancer specimens for K-Ras mutation using …
plays an important role in transducing extracellular signals to the nuclei of cells. It is located
in both the cytoplasm and the nucleus of cells. The nuclear localization of phosphorylated or
activated ERK is involved in the invasive behavior of tumor cells. We studied the association
between Ras mutation/ERK activation and the prognosis of patients with colorectal cancer.
We analyzed 126 surgically resected colorectal cancer specimens for K-Ras mutation using …