Genetic variants of the protein kinase C-β 1 gene and development of end-stage renal disease in patients with type 2 diabetes

RCW Ma, CHT Tam, Y Wang, AO Luk, C Hu, X Yang… - Jama, 2010 - jamanetwork.com
Context Protein kinase C-β (PKC-β) is a cell-signaling intermediate implicated in
development of diabetic complications. Objective To examine the risk association of PKC-β
1 gene (PRKCB1) polymorphisms and end-stage renal disease (ESRD) in an 8-year
prospective cohort of Chinese patients with type 2 diabetes. Design, Setting, and
Participants We genotyped 18 common tag single-nucleotide polymorphisms (SNPs) that
span the PRKCB1 gene (r 2= 0.80) in 1172 Chinese patients (recruited 1995-1998) without …