Genetic variants may increase susceptibility to both diabetes and kidney disease. Whether
known diabetes-associated variants in the transcription factor 7–like 2 (TCF7L2) gene are
associated with chronic kidney disease (CKD) progression and markers of kidney function is
unknown. Participants of the Atherosclerosis Risk in Communities Study (ARIC; n= 11,061
self-identified white and n= 4014 black), Framingham Heart Offspring Cohort (FHS; n=
2468), and Heredity and Phenotype Intervention Heart Study (HAPI; n= 861) were …