Isolation of a virus from the pancreas of a child with diabetic ketoacidosis.
JW Yoon, M Austin, T Onodera… - The New England journal …, 1979 - europepmc.org
A healthy 10-year-old boy was admitted to the hospital in diabetic ketoacidosis within three
days of onset of symptoms of a flu-like illness. He died seven days later and post-mortem
examination showed lymphocytic infiltration of the islets of Langerhans and necrosis of beta
cells. Inoculation of mouse, monkey and human cell cultures with homogenates from the
patient's pancreas led to isolation of a virus. Serologic studies revealed a rise in the titer of
neutralizing antibody to this virus from less than 4 on the second hospital day to 32 on the …
days of onset of symptoms of a flu-like illness. He died seven days later and post-mortem
examination showed lymphocytic infiltration of the islets of Langerhans and necrosis of beta
cells. Inoculation of mouse, monkey and human cell cultures with homogenates from the
patient's pancreas led to isolation of a virus. Serologic studies revealed a rise in the titer of
neutralizing antibody to this virus from less than 4 on the second hospital day to 32 on the …
Virus-induced diabetes mellitus: isolation of a virus from the pancreas of a child with diabetic ketoacidosis
JW Yoon, M Austin, T Onodera… - New England Journal of …, 1979 - Mass Medical Soc
A healthy 10-year-old boy was admitted to the hospital in diabetic ketoacidosis within three
days of onset of symptoms of a flu-like illness. He died seven days later and post-mortem
examination showed lymphocytic infiltration of the islets of Langerhans and necrosis of beta
cells. Inoculation of mouse, monkey and human cell cultures with homogenates from the
patient's pancreas led to isolation of a virus. Serologic studies revealed a rise in the titer of
neutralizing antibody to this virus from less than 4 on the second hospital day to 32 on the …
days of onset of symptoms of a flu-like illness. He died seven days later and post-mortem
examination showed lymphocytic infiltration of the islets of Langerhans and necrosis of beta
cells. Inoculation of mouse, monkey and human cell cultures with homogenates from the
patient's pancreas led to isolation of a virus. Serologic studies revealed a rise in the titer of
neutralizing antibody to this virus from less than 4 on the second hospital day to 32 on the …