[HTML][HTML] JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunction

J Yu, SA Novgorodov, D Chudakova, H Zhu… - Journal of Biological …, 2007 - ASBMB
A cardinal feature of brain tissue injury in stroke is mitochondrial dysfunction leading to cell
death, yet remarkably little is known about the mechanisms underlying mitochondrial injury
in cerebral ischemia/reperfusion (IR). Ceramide, a naturally occurring membrane
sphingolipid, functions as an important second messenger in apoptosis signaling and is
generated by de novo synthesis, sphingomyelin hydrolysis, or recycling of sphingolipids. In
this study, cerebral IR-induced ceramide elevation resulted from ceramide biosynthesis …