Cartilage not only plays essential roles in skeletal development and growth during pre-and
postnatal stages but also serves to provide smooth movement of skeletons throughout life.
Thus, dysfunction of cartilage causes a variety of skeletal disorders. Results from animal
studies reveal that β-catenin-dependent canonical and independent non-canonical Wnt
signaling pathways have multiple roles in regulation of cartilage development, growth, and
maintenance. β-Catenin-dependent signaling is required for progression of endochondral …