AKI is increasingly recognized as a major risk factor for progression to CKD. However, the
factors governing AKI to CKD progression are poorly understood. In this study, we
investigated this issue using moderate (20 minutes) and severe (30 minutes)
ischemia/reperfusion injury (IRI) in mice. Moderate IRI led to acute kidney failure and
transient Wnt/β-catenin activation, which was followed by the restoration of kidney
morphology and function. However, severe IRI resulted in sustained and exaggerated Wnt/β …