The molecular basis and potential role of survivin in cancer diagnosis and therapy
DC Altieri - Trends in molecular medicine, 2001 - cell.com
Trends in molecular medicine, 2001•cell.com
Despite its genetic complexity and multifactoriality, two processes appear almost universally
compromised in cancer: the control of cell proliferation and the regulation of cell lifespan.
Survivin is a recently described molecule that has been implicated in both processes, and is
overexpressed in most human cancers. The exploitation of the survivin signaling pathway
might provide important predictive and prognostic clues in cancer diagnosis, and offer new
therapeutic alternatives for cancer treatment.
compromised in cancer: the control of cell proliferation and the regulation of cell lifespan.
Survivin is a recently described molecule that has been implicated in both processes, and is
overexpressed in most human cancers. The exploitation of the survivin signaling pathway
might provide important predictive and prognostic clues in cancer diagnosis, and offer new
therapeutic alternatives for cancer treatment.
Abstract
Despite its genetic complexity and multifactoriality, two processes appear almost universally compromised in cancer: the control of cell proliferation and the regulation of cell lifespan. Survivin is a recently described molecule that has been implicated in both processes, and is overexpressed in most human cancers. The exploitation of the survivin signaling pathway might provide important predictive and prognostic clues in cancer diagnosis, and offer new therapeutic alternatives for cancer treatment.
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