[HTML][HTML] Heparin but not citrate anticoagulation of blood preserves platelet function for prolonged periods
NJ Truss, PCJ Armstrong, E Liverani, I Vojnovic… - Journal of Thrombosis …, 2009 - Elsevier
Background: Current guidelines state that platelet aggregation studies should be conducted
within 4 h of venepuncture because of the decline in sensitivity to platelet agonists. This
constrains studies of platelet activity in clinical situations where samples need to be
transported or there are unavoidable delays prior to assessment. Objectives: The aim of the
present study was to compare systematically the responses of platelets stored in the
presence of either citrate or heparin, the two most widely used anti‐coagulants, using a …
within 4 h of venepuncture because of the decline in sensitivity to platelet agonists. This
constrains studies of platelet activity in clinical situations where samples need to be
transported or there are unavoidable delays prior to assessment. Objectives: The aim of the
present study was to compare systematically the responses of platelets stored in the
presence of either citrate or heparin, the two most widely used anti‐coagulants, using a …