[HTML][HTML] Degradation of pulmonary surfactant protein D by Pseudomonas aeruginosa elastase abrogates innate immune function
JF Alcorn, JR Wright - Journal of Biological Chemistry, 2004 - ASBMB
The alveolar epithelium is lined by surfactant, a lipoprotein complex that both reduces
surface tension and mediates several innate immune functions including bacterial
aggregation, alteration of alveolar macrophage function, and regulation of bacterial
clearance. Surfactant protein-D (SP-D) participates in several of these immune functions,
and specifically it enhances the clearance of the pulmonary pathogen Pseudomonas
aeruginosa, a common cause of morbidity and mortality in cystic fibrosis (CF) patients. P …
surface tension and mediates several innate immune functions including bacterial
aggregation, alteration of alveolar macrophage function, and regulation of bacterial
clearance. Surfactant protein-D (SP-D) participates in several of these immune functions,
and specifically it enhances the clearance of the pulmonary pathogen Pseudomonas
aeruginosa, a common cause of morbidity and mortality in cystic fibrosis (CF) patients. P …