T helper cytokines in dry eye disease

SC Pflugfelder, RM Corrales, CS de Paiva - Experimental eye research, 2013 - Elsevier
Dry eye is an inflammatory disease that results from activation of innate inflammatory
pathways in resident ocular surface cells, as well as cytokines produced by recruited T
helper (Th) cells. Cytokines produced by the infiltrating Th cells alter the normal cytokine
balance on the ocular surface and cause ocular surface epithelial pathology. Changes in
levels of Th cytokines on the ocular surface have been measured in dry eye and the
biological effects of these cytokines have been documented in experimental culture and …