Dry eye is a highly prevalent immune disorder characterized by a dysfunctional tear film and
a Th1/Th17 T cell response at the ocular surface. The specificity of these pathogenic effector
T cells remains to be determined, but auto-reactivity is considered likely. However, we have
previously shown that ocular mucosal tolerance to an exogenous antigen is disrupted in a
scopolamine-induced murine dry eye model and that it is actually responsible for disease
progression. Here we report comparable findings in an entirely different murine model of dry …