[HTML][HTML] The colonic microbiome and epithelial transcriptome are altered in rats fed a high-protein diet compared with a normal-protein diet
Background: A high-protein diet (HPD) can produce hazardous compounds and reduce
butyrate-producing bacteria in feces, which may be detrimental to gut health. However,
information on whether HPD affects intestinal function is limited. Objective: The aim of this
study was to determine the impact of an HPD on the microbiota, microbial metabolites, and
epithelial transcriptome in the colons of rats. Methods: Adult male Wistar rats were fed either
a normal-protein diet (20% protein, 56% carbohydrate) or an HPD (45% protein, 30 …
butyrate-producing bacteria in feces, which may be detrimental to gut health. However,
information on whether HPD affects intestinal function is limited. Objective: The aim of this
study was to determine the impact of an HPD on the microbiota, microbial metabolites, and
epithelial transcriptome in the colons of rats. Methods: Adult male Wistar rats were fed either
a normal-protein diet (20% protein, 56% carbohydrate) or an HPD (45% protein, 30 …