MicroRNA-24 suppression of N-deacetylase/N-sulfotransferase-1 (NDST1) reduces endothelial cell responsiveness to vascular endothelial growth factor A (VEGFA)
Z Kasza, PF Fuchs, C Tamm, AS Eriksson… - Journal of Biological …, 2013 - jbc.org
Heparan sulfate (HS) proteoglycans, present at the plasma membrane of vascular
endothelial cells, bind to the angiogenic growth factor VEGFA to modulate its signaling
through VEGFR2. The interactions between VEGFA and proteoglycan co-receptors require
sulfated domains in the HS chains. To date, it is essentially unknown how the formation of
sulfated protein-binding domains in HS can be regulated by microRNAs. In the present
study, we show that microRNA-24 (miR-24) targets NDST1 to reduce HS sulfation and …
endothelial cells, bind to the angiogenic growth factor VEGFA to modulate its signaling
through VEGFR2. The interactions between VEGFA and proteoglycan co-receptors require
sulfated domains in the HS chains. To date, it is essentially unknown how the formation of
sulfated protein-binding domains in HS can be regulated by microRNAs. In the present
study, we show that microRNA-24 (miR-24) targets NDST1 to reduce HS sulfation and …