[HTML][HTML] Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling
Y Mishina, MW Starbuck, MA Gentile, T Fukuda… - Journal of Biological …, 2004 - ASBMB
Bone morphogenetic proteins (BMPs) function during various aspects of embryonic
development including skeletogenesis. However, their biological functions after birth are
less understood. To investigate the role of BMPs during bone remodeling, we generated a
postnatal osteoblast-specific disruption of Bmpr1a that encodes the type IA receptor for
BMPs in mice. Mutant mice were smaller than controls up to 6 months after birth. Irregular
calcification and low bone mass were observed, but there were normal numbers of …
development including skeletogenesis. However, their biological functions after birth are
less understood. To investigate the role of BMPs during bone remodeling, we generated a
postnatal osteoblast-specific disruption of Bmpr1a that encodes the type IA receptor for
BMPs in mice. Mutant mice were smaller than controls up to 6 months after birth. Irregular
calcification and low bone mass were observed, but there were normal numbers of …