Osteoprotegerin (OPG) is an essential secreted protein in bone turnover due to its role as a
decoy receptor for the Receptor Activator of Nuclear Factor-kB ligand (RANKL) in the
osteoclasts, thus inhibiting their differentiation. However, there are additional ligands of OPG
that confer various biological functions. OPG can promote cell survival, cell proliferation and
facilitates migration by binding TNF-related apoptosis inducing ligand (TRAIL),
glycosaminoglycans or proteoglycans. A large number of in vitro, pre-clinical and clinical …