The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling
S Theoleyre, Y Wittrant, SK Tat, Y Fortun… - Cytokine & growth factor …, 2004 - Elsevier
The past decade has seen an explosion in the field of bone biology. The area of bone
biology over this period of time has been marked by a number of key discoveries that have
opened up entirely new areas for investigation. The recent identification of the receptor
activator of nuclear factor κB ligand (RANKL), its cognate receptor RANK, and its decoy
receptor osteoprotegerin (OPG) has led to a new molecular perspective on osteoclast
biology and bone homeostasis. Specifically, the interaction between RANKL and RANK has …
biology over this period of time has been marked by a number of key discoveries that have
opened up entirely new areas for investigation. The recent identification of the receptor
activator of nuclear factor κB ligand (RANKL), its cognate receptor RANK, and its decoy
receptor osteoprotegerin (OPG) has led to a new molecular perspective on osteoclast
biology and bone homeostasis. Specifically, the interaction between RANKL and RANK has …